Omics analysis reveals galectin-3 to be a potential key regulator of allergic inflammation in hereditary angioedema
Galectin-3 plays a critical role in eosinophil recruitment and airway allergic inflammation. It may contribute to chronic inflammation and fibrosis resulting in leaky vasculature, and it could be a potential therapeutic target in HAE-III.
Authors
- Berhane Ghebrehiwet (ORCID: https://orcid.org/0000-0001-5803-6872)
- Janvhi Machhar
- Supriya D. Mahajan (ORCID: https://orcid.org/0000-0002-5298-6962)
- Stanley A. Schwartz (ORCID: https://orcid.org/0000-0002-8664-1380)
- Ravikumar Aalinkeel (ORCID: https://orcid.org/0000-0003-0883-4061)
- Jessica L. Reynolds (ORCID: https://orcid.org/0000-0001-5188-6786)
Institutions
- Stony Brook Medicine (US)
- Jacobs Institute (US)
- Stony Brook University (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.jacig.2024.100353
- Citations
- 1
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- Takeda Pharmaceutical Company
- Stony Brook University
- Takeda Canada