Blood expression of NADK2 as a diagnostic biomarker for sciatica
Sciatica is characterized by radiating pain along the sciatic nerve, with a lifetime prevalence of up to 43%. This study explored blood biomarkers for sciatica using transcriptomic microarray data (GSE124272 and GSE150408). Differential gene expression analysis identified NADK2 as a potential diagnostic biomarker. A diagnostic model based on NADK2 showed strong validation performance in 200 clinical cases. Gene set enrichment analysis (GSEA) suggested a connection between NADK2 and the aminoacyl-tRNA biosynthesis pathway. In conclusion, NADK2 emerges as promising diagnostic and therapeutic targets for sciatica, significantly advancing our comprehension of potential pathogenic mechanisms and offering perspectives for early diagnosis and treatment.
Authors
- Zhong Ren (ORCID: https://orcid.org/0000-0001-7098-3127)
- Xiaobo Wang (ORCID: https://orcid.org/0000-0003-2145-6616)
- Jiawei Shi
- Yang Wang (ORCID: https://orcid.org/0000-0003-1270-3531)
- Xin Zheng (ORCID: https://orcid.org/0000-0002-4153-8515)
- Bingyu Wang
- Jingmin Liu
Institutions
- Sun Yat-sen University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- iScience
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.isci.2024.111196
- Citations
- 2
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 0.93
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Guangdong Province
- Southern Medical University
- Nanfang Hospital