Population clustering of structural brain aging and its association with brain development
Structural brain aging has demonstrated strong inter-individual heterogeneity and mirroring patterns with brain development. However, due to the lack of large-scale longitudinal neuroimaging studies, most of the existing research focused on the cross-sectional changes of brain aging. In this investigation, we present a data-driven approach that incorporate both cross-sectional changes and longitudinal trajectories of structural brain aging and identified two brain aging patterns among 37,013 healthy participants from UK Biobank. Participants with accelerated brain aging also demonstrated accelerated biological aging, cognitive decline and increased genetic susceptibilities to major neuropsychiatric disorders. Further, by integrating longitudinal neuroimaging studies from a multi-center adolescent cohort, we validated the ‘last in, first out’ mirroring hypothesis and identified brain regions with manifested mirroring patterns between brain aging and brain development. Genomic analyses revealed risk loci and genes contributing to accelerated brain aging and delayed brain development, providing molecular basis for elucidating the biological mechanisms underlying brain aging and related disorders.
Authors
- Andreas Heinz (ORCID: https://orcid.org/0000-0001-5405-9065)
- Sylvane Desrivières (ORCID: https://orcid.org/0000-0002-9120-7060)
- Hugh P Garavan (ORCID: https://orcid.org/0000-0002-8939-1014)
- Rüdiger Brühl (ORCID: https://orcid.org/0000-0003-0111-5996)
- Runye Shi (ORCID: https://orcid.org/0000-0002-1388-2079)
- Tobias Banaschewski (ORCID: https://orcid.org/0000-0003-4595-1144)
- Jianfeng Feng (ORCID: https://orcid.org/0000-0001-5987-2258)
- Jujiao Kang (ORCID: https://orcid.org/0000-0002-4489-7281)
- Sarah Hohmann (ORCID: https://orcid.org/0000-0002-5175-6698)
- Jean‐Luc Martinot (ORCID: https://orcid.org/0000-0002-0136-0388)
- Marie‐Laure Paillère Martinot (ORCID: https://orcid.org/0000-0002-0452-2450)
- Arun L.W. Bokde (ORCID: https://orcid.org/0000-0003-0114-4914)
- Juliane H. Fröhner (ORCID: https://orcid.org/0000-0002-8493-6396)
- Christian Büchel (ORCID: https://orcid.org/0000-0003-1965-906X)
- Antoine Grigis (ORCID: https://orcid.org/0000-0001-7984-3710)
- Robert Whelan (ORCID: https://orcid.org/0000-0002-2790-7281)
- Henrik Walter (ORCID: https://orcid.org/0000-0002-9403-6121)
- Luise Poustka (ORCID: https://orcid.org/0000-0002-7738-4394)
- Xiaolei Lin (ORCID: https://orcid.org/0000-0003-2463-1272)
- Michael N. Smolka (ORCID: https://orcid.org/0000-0001-5398-5569)
- Dimitri Papadopoulos Orfanos (ORCID: https://orcid.org/0000-0002-1242-8990)
- Frauke Nees (ORCID: https://orcid.org/0000-0002-7796-8234)
- Penny Anne Gowland (ORCID: https://orcid.org/0000-0002-4900-4817)
- Eric Artiges A (ORCID: https://orcid.org/0000-0003-4461-7646)
- Günter Schumann (ORCID: https://orcid.org/0000-0002-7740-6469)
- Haojing Duan
- Nathalie Nathalie Holz
- Herta Flor
- Nilakshi Vaidya
Institutions
- University of Vermont (US)
- Physikalisch-Technische Bundesanstalt (DE)
- Centre National de la Recherche Scientifique (FR)
- University of Nottingham (GB)
- Inserm (FR)
- Universität Hamburg (DE)
- University of Mannheim (DE)
- King's College London (GB)
- Trinity College Dublin (IE)
- Heidelberg University (DE)
- Fudan University (CN)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- University Hospital Heidelberg (DE)
- University Medical Center (US)
- École Normale Supérieure - PSL (FR)
- Christian-Albrechts-Universität zu Kiel (DE)
- Humboldt-Universität zu Berlin (DE)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Central Institute of Mental Health (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Hospital and Clinics (US)
- Pitié-Salpêtrière Hospital (FR)
- CEA Paris-Saclay (FR)
- University Clinical Centre (PL)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Eppendorf (Belgium) (BE)
- Electronic Product Services (Czechia) (CZ)
- Global Brain Health Institute (US)
- Huashan Hospital (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- Freie Universität Berlin (DE)
- Technische Universität Dresden (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- eLife
- Published
- 2024-10-18
- DOI
- https://doi.org/10.7554/elife.94970.3
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondation de l'Avenir pour la Recherche Médicale Appliquée
- Shanghai Center for Brain Science and Brain-Inspired Technology
- Deutsche Forschungsgemeinschaft
- National Natural Science Foundation of China
- Fondation pour la Recherche Médicale
- Fondation de France
- Fédération pour la Recherche sur le Cerveau
- Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives
- Higher Education Discipline Innovation Project
- National Institutes of Health
- Medical Research Council
- Horizon 2020
- National Key Research and Development Program of China
- National Institute for Health Research Applied Research Collaboration South London
- Medical Research Foundation