Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro
Imatinib exposure ex vivo and in vitro impinges on male rodent germ cell proliferation and survival. The plausible mechanism in spermatogenic cells is the inhibition of SCF/c-KIT signaling, and reduced expression of c-KIT. Dasatinib did not show significant adverse effects with clinical doses ex vivo but inhibited mGSC colony growth in vitro.
Authors
- M. Nieminen
- Opeyemi Olotu (ORCID: https://orcid.org/0000-0002-8759-1602)
- Jorma Toppari (ORCID: https://orcid.org/0000-0003-2228-334X)
- Anna Eggert (ORCID: https://orcid.org/0000-0002-3640-1960)
- Mirja Nurmio (ORCID: https://orcid.org/0000-0002-3278-639X)
- Aida Wahlgren
- Juho‐Antti Mäkelä (ORCID: https://orcid.org/0000-0001-8489-8724)
- Noora Kotaja (ORCID: https://orcid.org/0000-0003-1503-9170)
- Kirsi Jahnukainen
- Kim Eerola (ORCID: https://orcid.org/0000-0001-7882-2977)
- Sini Laasanen
Institutions
- Åbo Akademi University (FI)
- Karolinska University Hospital (SE)
- University of Helsinki (FI)
- University of Turku (FI)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Andrology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1111/andr.13777
- Citations
- 2
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Suomen Lääketieteen Säätiö
- European Commission
- Jane ja Aatos Erkon Säätiö
- Karolinska Institutet
- Novo Nordisk
- Emil Aaltosen Säätiö
- Turun Yliopisto
- Lastentautien Tutkimussäätiö
- Barncancerfonden
- Suomalainen Lääkäriseura Duodecim
- Syöpäsäätiö
- Turun Yliopistollinen Keskussairaala