Varoglutamstat: Inhibiting Glutaminyl Cyclase as a Novel Target of Therapy in Early Alzheimer’s Disease
Varoglutamstat provides a unique dual mechanism of action addressing multiple pathogenic contributors to the disease cascade. VIVA-MIND provides a novel and efficient trial design to establish its optimal dosing, safety, tolerability, and efficacy in early AD.
Authors
- Amanda Smith (ORCID: https://orcid.org/0000-0002-8951-8564)
- Carolyn Revta
- Yuqi Qiu (ORCID: https://orcid.org/0009-0006-9559-0104)
- January Durant (ORCID: https://orcid.org/0000-0002-6792-1539)
- Howard Feldman (ORCID: https://orcid.org/0000-0002-9258-4538)
- Diane M. Jacobs (ORCID: https://orcid.org/0000-0003-0886-6784)
- Jody‐Lynn Lupo (ORCID: https://orcid.org/0000-0002-9323-5727)
- Marwan Sabbagh
- Karen Messer (ORCID: https://orcid.org/0000-0002-9298-2413)
- David P. Salmon (ORCID: https://orcid.org/0000-0003-4533-4090)
- Mari L. DeMarco
- Raymond Scott Turner (ORCID: https://orcid.org/0000-0001-7534-2935)
- Lorna M. Lopez (ORCID: https://orcid.org/0000-0002-0241-9783)
- Frank Weber (ORCID: https://orcid.org/0000-0002-4842-7922)
- Gabriel C. Léger (ORCID: https://orcid.org/0000-0001-7900-3957)
- Archana Balasubramanian
- Douglas Galasko
- Kerstin Kuehn-Wache
- Tanja Wassmann
- Sylvia Schell-Mader
Institutions
- Providence Health Care (CA)
- Barrow Neurological Institute (US)
- University of British Columbia (CA)
- University of Pittsburgh (US)
- Georgetown University (US)
- University of California San Diego (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- USF Health Byrd Alzheimer's Institute (US)
- Ribon Therapeutics (United States) (US)
- East China Normal University (CN)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3233/jad-231126
- Citations
- 12
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.92
Funders
- Florida Department of Health
- Ohio State University
- Emory University
- Northwestern University
- Syracuse University
- State University of New York
- Georgetown University
- University of South Florida
- Cedars-Sinai Medical Center
- York University
- National Institutes of Health
- University of California, San Diego
- University of California, Irvine
- State University of New York Upstate Medical University
- Roy J. and Lucille A. Carver College of Medicine, University of Iowa
- Goizueta Business School, Emory University