Alkylcyanation of Unactivated Alkenes with Protic C(sp<sup>3</sup>)−H Feedstocks via Radical‐Initiated Intramolecular Cyano Group Migration Enabled by Photoredox/Brønsted Base Dual Catalysis
Abstract Cyanofunctionalization of alkenes via radical‐initiated cyano migration was a straightforward pathway to access alkyl nitriles. Herein, By the synergistic merger of photoredox catalysis and Brønsted base catalysis, a mild protocol of alkylcyanation of unactivated alkenes with protic C(sp 3 )−H feedstocks via intramolecular 1,4‐cyano group migration was reported. This method was enabled in an atom‐, and step‐economy manner, delivering a series of γ‐cyanoester derivatives in moderate to excellent yields.
Authors
- Hong‐Ping Deng (ORCID: https://orcid.org/0000-0003-4611-337X)
- Yang Hong (ORCID: https://orcid.org/0000-0002-9753-0176)
Institutions
- Nanjing Agricultural University (CN)
- Anqing Normal University (CN)
Publication Details
- Journal
- ChemPhotoChem
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1002/cptc.202400282
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- National Natural Science Foundation of China