Global burden of vaccine-associated uveitis and their related vaccines, 1967–2023
Although uveitis after vaccination is rare, reports emerged during the COVID-19 pandemic. We used the pharmacovigilance case/non-case study from 1967 to 2023 to assess the association between vaccines and uveitis. We identified a significant signal for uveitis (reporting OR (ROR), 1.64; information component (IC)<sub>025</sub>, 0.66) with 1508 reports. This association is pronounced in females of all ages after childhood. Specifically, the COVID-19 messenger RNA vaccines showed the strongest disproportionality signal (ROR, 5.76; IC<sub>025</sub>, 2.33), followed by hepatitis B, papillomavirus, Ad (Adenovirus) 5-vectored COVID-19 and influenza vaccines. These findings underscore the importance of surveillance in the postmarketing phase to manage potential adverse events associated with vaccine administration.
Authors
- Jaeyu Park (ORCID: https://orcid.org/0009-0005-2009-386X)
- Hayeon Lee (ORCID: https://orcid.org/0009-0000-2403-6241)
- Raphael Udeh (ORCID: https://orcid.org/0000-0002-9476-6677)
- Dong Keon Yon (ORCID: https://orcid.org/0000-0003-1628-9948)
- Jee Myung Yang (ORCID: https://orcid.org/0000-0001-5729-2233)
- Masoud Rahmati (ORCID: https://orcid.org/0000-0003-4792-027X)
- Seoyoung Park (ORCID: https://orcid.org/0009-0008-4115-2947)
- Joo Yong Lee (ORCID: https://orcid.org/0000-0002-2187-196X)
- Jiyeon Oh (ORCID: https://orcid.org/0009-0005-3291-4370)
- Hyesu Jo
Institutions
- University of Technology Sydney (AU)
- Ulsan College (KR)
- Aix-Marseille Université (FR)
- Asan Medical Center (KR)
- Vali Asr University of Rafsanjan (IR)
- Lorestan University (IR)
- Kyung Hee University (KR)
- University of Ulsan (KR)
- Assistance Publique Hôpitaux de Marseille (FR)
Publication Details
- Journal
- British Journal of Ophthalmology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1136/bjo-2024-325985
- Citations
- 3
- Primary Topic
- Retinal and Optic Conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.62