ANA-positive <i>versus</i> ANA-negative Antiphospholipid Antibody-positive Patients: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Clinical Database and Repository (“Registry”)
When we analysed aPL-positive patients with no other SARDs, ANA status was not associated with thrombosis or pregnancy morbidity. Interestingly, ANA+ patients showed higher rates of systemic autoimmune features, including haematologic manifestations, multiple aPL positivity, lower complement levels, ENA positivity, and joint involvement, and were more often treated with HCQ. Finally, aPL-positive subjects who were ANA- had a higher rate of pregnancies and live births.
Authors
- Esther Rodríguez-Almaraz (ORCID: https://orcid.org/0000-0003-0839-5644)
- Guillermo Ruiz‐Irastorza (ORCID: https://orcid.org/0000-0001-7788-1043)
- Guilherme Ramires de Jesús (ORCID: https://orcid.org/0000-0002-6715-0180)
- Vittorio Pengo (ORCID: https://orcid.org/0000-0003-2064-6071)
- Irene Cecchi (ORCID: https://orcid.org/0000-0002-1858-5452)
- Maria Efthymiou (ORCID: https://orcid.org/0000-0001-9704-2845)
- Savino Sciascia (ORCID: https://orcid.org/0000-0003-1266-9441)
- María Laura Bertolaccini (ORCID: https://orcid.org/0000-0002-8623-139X)
- Bahar Artım-Esen (ORCID: https://orcid.org/0000-0002-5659-3955)
- Ricard Cervera (ORCID: https://orcid.org/0000-0001-6085-492X)
- Cecilia Nalli (ORCID: https://orcid.org/0000-0003-2514-9891)
- Lanlan Ji (ORCID: https://orcid.org/0000-0001-9620-8882)
- Massimo Radin (ORCID: https://orcid.org/0000-0003-1941-2606)
- H. Michael Belmont (ORCID: https://orcid.org/0000-0003-3389-2976)
- Rohan Willis (ORCID: https://orcid.org/0000-0002-1374-7678)
- Alice Barinotti (ORCID: https://orcid.org/0000-0002-7354-7002)
- C. López-Pedrera (ORCID: https://orcid.org/0000-0003-2067-4603)
- D. Ware Branch (ORCID: https://orcid.org/0000-0002-1718-5094)
- Hannah Cohen (ORCID: https://orcid.org/0000-0003-2032-390X)
- Silvia Grazietta Foddai
- Maria Gerosa (ORCID: https://orcid.org/0000-0001-5241-5847)
- Maria G. Tektonidou (ORCID: https://orcid.org/0000-0003-2238-0975)
- Paul R. Fortin (ORCID: https://orcid.org/0000-0002-7278-2596)
- Tatsuya Atsumi (ORCID: https://orcid.org/0000-0001-5657-962X)
- Jason S. Knight (ORCID: https://orcid.org/0000-0003-0995-9771)
- Danieli Andrade (ORCID: https://orcid.org/0000-0002-0381-1808)
- Doruk Erkan
- Michelle Petri
Institutions
- Intermountain Healthcare (US)
- Hospital for Special Surgery (US)
- University of Padua (IT)
- Johns Hopkins University (US)
- Universidade de São Paulo (BR)
- King's College London (GB)
- University of Milan (IT)
- National and Kapodistrian University of Athens (GR)
- Peking University (CN)
- Cornell University (US)
- University of Utah (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- Brescia University (US)
- Universidade do Estado do Rio de Janeiro (BR)
- NYU Langone Health (US)
- BioCruces Health research Institute (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Hospital Universitario 12 De Octubre (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Department of Medical Sciences (BY)
- Peking University First Hospital (CN)
- Hokkaido University Hospital (JP)
- Hospital Universitário da Universidade de São Paulo (BR)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Université Laval (CA)
- University College London (GB)
- University of Turin (IT)
- The University of Texas Medical Branch at Galveston (US)
- Istanbul University (TR)
- Universitat de Barcelona (ES)
- University of Brescia (IT)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1093/rheumatology/keae583
- Citations
- 6
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 2.82
Funders
- Weill Cornell Medical College