Direct-Acting Oral Anticoagulants and Potential Inconsistencies with FDA-Approved Dosing for Non-Valvular Atrial Fibrillation: A Retrospective Real-World Analysis Across Nine US Healthcare Systems
DOAC dosing inconsistent with label varied by demographics, clinical characteristics, prescriber specialty, and healthcare system, suggesting a need to monitor and assess dosing decisions in NVAF. Identification of variables associated with dosing inconsistencies may enable targeted interventions to ensure label-consistent dosing in vulnerable populations.
Authors
- Eryne E. Wiethorn (ORCID: https://orcid.org/0000-0003-4988-7485)
- Bonnie DeLor
- Carmen Gust (ORCID: https://orcid.org/0000-0002-6788-3130)
- Sara A. Hart (ORCID: https://orcid.org/0000-0001-9793-0420)
- Shelby Kelsh (ORCID: https://orcid.org/0000-0002-9606-8354)
- Steven Naylor
- Gregory Fakelmann
- Laura Duvall
- Charles Medico
- Richard W. Dettloff (ORCID: https://orcid.org/0000-0001-8627-7841)
- Ukwen Akpoji (ORCID: https://orcid.org/0000-0003-4611-5869)
- Angela Child (ORCID: https://orcid.org/0000-0002-7388-4607)
- Robert D. Bowen
- Heather Somand
- Chiahung Chou (ORCID: https://orcid.org/0000-0002-0786-8182)
- Timothy J. Hartman (ORCID: https://orcid.org/0000-0003-3937-3480)
- Laura L. Manzey
- Jaclynne Gowen
- Ann Parks (ORCID: https://orcid.org/0000-0001-9779-6049)
- Mohammad Ateya (ORCID: https://orcid.org/0000-0002-9345-4049)
- Christina Wadsworth
- Alexander J Ansara
- Trang D Trinh (ORCID: https://orcid.org/0000-0002-9928-4714)
- Jennifer Stanton
- Jon Glover
- Wesley R. Zemrak (ORCID: https://orcid.org/0000-0002-5046-7966)
- L. Davis (ORCID: https://orcid.org/0000-0002-9899-7667)
- William W. Wilson
- Katie Taylor
- Saira Naim Haqu
- Saba Sarsam
Institutions
- Indiana University Health (US)
- MetroHealth (US)
- Pfizer (United States) (US)
- Ferris State University (US)
- MaineHealth (US)
- ThedaCare (US)
- Wentworth Douglass Hospital (US)
- Parkview Health (US)
- Baptist Health Louisville (US)
- Mass General Brigham (US)
- HealthPartners (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Journal of General Internal Medicine
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1007/s11606-024-09106-w
- Citations
- 3
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Bristol-Myers Squibb
- Pfizer
- Massachusetts General Hospital