Aging-induced dysbiosis worsens sepsis severity but is attenuated by probiotics in D-galactose-administered mice with cecal ligation and puncture model
D-gal induced fecal dysbiosis and worsened sepsis severity as determined by Scr and ALT, and LGG could alleviate most of the selected parameters of sepsis, including SAE. However, the impact of LGG on SAE was not a direct delivery of beneficial molecules from the gut to the brain but partly due to the attenuation of systemic inflammation through the modulation of macrophages.
Authors
- Kanyarat Udompornpitak (ORCID: https://orcid.org/0000-0002-0928-1801)
- Asada Leelahavanichkul (ORCID: https://orcid.org/0000-0002-5566-6403)
- Wimonrat Panpetch (ORCID: https://orcid.org/0000-0002-0455-6757)
- Thansita Bhunyakarnjanarat
- Peerapat Visitchanakun
- Dhammika Leshan Wannigama (ORCID: https://orcid.org/0000-0001-6316-1221)
- Monruedee Sukprasansap (ORCID: https://orcid.org/0000-0003-0205-7337)
- Tewin Tencomnao (ORCID: https://orcid.org/0000-0003-4177-2165)
- Pattarin Tangtanatakul (ORCID: https://orcid.org/0000-0001-8978-6916)
- Suwasin Udomkarnjananun (ORCID: https://orcid.org/0000-0003-4087-9032)
- Chalisa Pinitchun
- Huy Thanh
Institutions
- Burapha University (TH)
- Chulalongkorn University (TH)
- The University of Western Australia (AU)
- Mahidol University (TH)
- Yamagata Prefectural Central Hospital (JP)
- University of Sheffield (GB)
- Yamagata Prefectural University of Health Sciences (JP)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1371/journal.pone.0311774
- Citations
- 10
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.57
Funders
- Chulalongkorn University
- National Research Council of Thailand
- Thailand Science Research and Innovation