Synthesis and antimicrobial activity of novel pyrido[2,3-d]pyrimidin-4(1H)-ones, and 2-pyrazoline derivatives

The synthesis of thienyl indoyl chalcone produced a novel group of compounds bearing indole and thiophene moieties.The new series of substituted pyridines, 2-pyrazolines, and azepines were synthesized.2-Aminopyridines were produced by reacting chalcone with active methylene reagents.The chalcone were converted to pyrimidinones.These compounds served as the initial substrate for the synthesis 1thiocarbamoyl-2-pyrazoline.1-(4-oxo-5H-thiazolyl)-2-pyrazoline and 1-(4-phenylthiazolyl)-2-pyrazoline were synthesized by treating 1-thiocarbamoyl pyrazoline with chloroacetic acid or phenacyl bromide.The chalcone underwent a reaction with bifunctional agents resulting in the formation of azepines.The compounds were structurally determined with spectral data and they were tested for antimicrobial activity giving reasonable results.