Intraspecific venom variation in the medically important puff adder (Bitis arietans): Comparative venom gland transcriptomics, in vitro venom activity and immunological recognition by antivenom
The large distribution and medical importance of B. arietans makes this species ideal for understanding venom variation and the impact this has on therapeutic efficacy. The findings in this study highlight the likelihood for considerable venom toxin variation across the range of B. arietans, but that this may not dramatically impact upon the utility of treatment available in the region.
Authors
- Mark C. Wilkinson (ORCID: https://orcid.org/0000-0003-3109-6888)
- Charlotte A. Dawson (ORCID: https://orcid.org/0000-0003-3922-9518)
- Keirah E. Bartlett (ORCID: https://orcid.org/0000-0003-3497-1385)
- Rachel H. Clare (ORCID: https://orcid.org/0000-0002-3945-0530)
- Robert A. Harrison (ORCID: https://orcid.org/0000-0001-9842-5573)
- Simon C. Wagstaff (ORCID: https://orcid.org/0000-0003-0577-5537)
- Cassandra M. Modahl (ORCID: https://orcid.org/0000-0003-2211-3930)
- Laura-Oana Albulescu (ORCID: https://orcid.org/0000-0001-6563-9217)
- Steven R. Hall (ORCID: https://orcid.org/0000-0001-5314-4970)
- Adam Westhorpe (ORCID: https://orcid.org/0000-0002-7499-9174)
- Nicholas R. Casewell (ORCID: https://orcid.org/0000-0002-8035-4719)
- Stuart Ainsworth (ORCID: https://orcid.org/0000-0002-0199-6482)
- Taline Kazandijan
Institutions
- University of Liverpool (GB)
- Liverpool School of Tropical Medicine (GB)
- Lancaster University (GB)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1371/journal.pntd.0012570
- Citations
- 7
- Primary Topic
- Venomous Animal Envenomation and Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.85
Funders
- Medical Research Council