Longitudinal monitoring of circulating tumor DNA to detect relapse early and predict outcome in early breast cancer
PCM detected ctDNA in patients who relapsed with a long lead-time over clinical relapse, shows strong association with relapse-free survival and may be used to identify patients at high-risk for relapse, allowing for earlier intervention.
Authors
- Alistair Ring (ORCID: https://orcid.org/0000-0003-1230-2973)
- David J. Wooten (ORCID: https://orcid.org/0000-0002-0067-123X)
- Isaac García-Murillas (ORCID: https://orcid.org/0000-0001-8183-7969)
- Abigail Evans
- Robert Daber
- Rachel E. Ellsworth (ORCID: https://orcid.org/0000-0003-2287-1635)
- Duncan Wheatley (ORCID: https://orcid.org/0000-0002-1919-5114)
- Stephen Johnston (ORCID: https://orcid.org/0000-0002-9072-2749)
- Edward Phillips
- Benjamin Hubert
- W. Michael Korn (ORCID: https://orcid.org/0000-0002-0124-6841)
- Chiharu Graybill
- Rosalind Cutts (ORCID: https://orcid.org/0000-0002-8297-9341)
- Sarah Hrebien
- Nicholas C. Turner (ORCID: https://orcid.org/0000-0001-8937-0873)
- Simon Russell (ORCID: https://orcid.org/0000-0001-9447-1169)
- Giselle Walsh-Crestani
- Kathryn Dunne (ORCID: https://orcid.org/0009-0007-7259-744X)
- Jianhua Zhao (ORCID: https://orcid.org/0009-0008-7239-3604)
- Ian E. Smith
- Anthony Skene
- Kally Sidhu
- Peter M. DeFord
Institutions
- Institute of Cancer Research (GB)
- University of California, San Francisco (US)
- Royal Cornwall Hospital Trust (GB)
- Royal Cornwall Hospital (GB)
- Breast Cancer Now (GB)
- Royal Bournemouth Hospital (GB)
- Poole Hospital (GB)
- LabCorp (United States) (US)
- Hinchingbrooke Hospital (GB)
- Royal Marsden Hospital (GB)
- Invitae (United States) (US)
Publication Details
- Journal
- Breast Cancer Research and Treatment
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1007/s10549-024-07508-2
- Citations
- 32
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 9.12
Funders
- Invitae
- National Institute for Health and Care Research