Aggregation-Induced Emission Luminogen Based Wearable Visible-Light Penetrator for Deep Photodynamic Therapy
Photodynamic therapy (PDT) has emerged as a preferred nonsurgical treatment in clinical applications due to its capacity to selectively eradicate diseased tissues while minimizing damage to normal tissue. Nevertheless, its clinical efficacy is constrained by the limited penetration of visible light. Although near-infrared (NIR) lasers offer enhanced tissue penetration, the dearth of suitable photosensitizers and a pronounced imaging-treatment disparity pose challenges. Additionally, clinical implementation via optical fiber implantation carries infection risks and necessitates minimally invasive surgery, contradicting PDT's noninvasive advantage. In this study, we introduce a brilliant approach utilizing aggregation-induced emission luminogens (AIEgen) to develop a visible-light penetrator (VLP), coupled with wireless light emitting diodes (LEDs), enabling deep photodynamic therapy. We validate the therapeutic efficacy of this visible-light penetrator in tissues inaccessible to conventional PDT, demonstrating significant suppression of inflammatory diffusion <i>in vivo</i> using AIEgen TBPPM loaded within the VLP, which exhibits a transmittance of 86% in tissues with a thickness of 3 mm. This innovative visible-light penetrator effectively overcomes the substantial limitations of PDT in clinical settings and holds promise for advancing phototherapy.
Authors
- Ryan T. K. Kwok (ORCID: https://orcid.org/0000-0002-6866-3877)
- Jianwei Sun (ORCID: https://orcid.org/0000-0002-2470-1077)
- Gang He (ORCID: https://orcid.org/0000-0002-5319-7084)
- Jacky W. Y. Lam
- Zhuojian Li (ORCID: https://orcid.org/0000-0001-5450-7219)
- Kun Zhou (ORCID: https://orcid.org/0000-0003-0782-3491)
- Zheng Qing Zhao (ORCID: https://orcid.org/0000-0002-5536-0439)
- Ben Zhong Tang (ORCID: https://orcid.org/0000-0002-0293-964X)
- Letian Xu (ORCID: https://orcid.org/0000-0003-3336-9907)
- Yong Liu (ORCID: https://orcid.org/0000-0003-4079-2156)
- Siyuan Wang (ORCID: https://orcid.org/0000-0002-8668-4057)
- Ying Yu (ORCID: https://orcid.org/0000-0001-5964-663X)
Institutions
- Hohai University (CN)
- Hong Kong University of Science and Technology (HK)
- Guangzhou Design Institute (CN)
- Frontier Science Foundation (CH)
- Chinese University of Hong Kong, Shenzhen (CN)
- State Key Laboratory of Luminescent Materials and Devices
- Institute of Science and Technology
- Xi'an Jiaotong University (CN)
- AGCO (Netherlands) (NL)
- University of Hong Kong (HK)
- South China University of Technology (CN)
Publication Details
- Journal
- ACS Nano
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1021/acsnano.4c10452
- Citations
- 18
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 3.32
Funders
- National Natural Science Foundation of China
- Innovation and Technology Commission
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Guangzhou Municipal Science and Technology Project
- National Key Research and Development Program of China
- Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology
- Basic and Applied Basic Research Foundation of Guangdong Province