Candida auris MIC testing by EUCAST and clinical and laboratory standards institute broth microdilution, and gradient diffusion strips; to be or not to be amphotericin B resistant?
The EUCAST and CLSI MIC results were in close agreement, whereas the strip test showed wider and bimodal distributions with reader to reader and centre to centre variation. Our study adds to the concern for commercial MIC testing of amphotericin B against C. auris and suggests the current breakpoint leads to random susceptibility classification.
Authors
- Shawn R. Lockhart (ORCID: https://orcid.org/0000-0002-4383-5994)
- Maiken Cavling Arendrup (ORCID: https://orcid.org/0000-0002-4747-0144)
- Nathan P. Wiederhold (ORCID: https://orcid.org/0000-0002-2225-5122)
Institutions
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Centers for Disease Control and Prevention (US)
- The University of Texas at San Antonio Health Science Center (US)
- Copenhagen University Hospital (DK)
Publication Details
- Journal
- Clinical Microbiology and Infection
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.cmi.2024.10.010
- Citations
- 16
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 6.22
Funders
- University of Texas at San Antonio
- European Society of Clinical Microbiology and Infectious Diseases
- Statens Serum Institut