Inflammation is associated with pain and fatigue in older adults
Our study adds to a growing body of literature showing that inflammation is associated with greater pain and fatigue in older adults. Our longitudinal data showing temporal bidirectional associations is consistent with evidence from non-human animal models that heightened inflammation causally contributes to fatigue and also suggests that the experience of pain and fatigue may contribute to inflammation. It will be important for future work to identify how lifestyle factors associated with pain and fatigue (e.g., physical activity) may contribute to these associations.
Authors
- Lauren Blaydon
- Ryan Bogdan (ORCID: https://orcid.org/0000-0002-1430-1045)
- Patrick L. Hill (ORCID: https://orcid.org/0000-0001-5902-6051)
- Alex P. Miller (ORCID: https://orcid.org/0000-0001-9163-8947)
- Thomas F. Oltmanns
- Sara A. Norton (ORCID: https://orcid.org/0000-0001-6276-0695)
- Megan Niehaus
Institutions
- Washington University in St. Louis (US)
- University of Missouri–St. Louis (US)
- Saint Louis University (US)
- Hologic (Germany) (DE)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.bbih.2024.100874
- Citations
- 7
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- National Institute on Aging