Enhancing GFPT1 expression with glutamine protects chondrocytes in osteoarthritis
Our findings demonstrate that GFPT1 is downregulated in OA, and overexpressing GFPT1 can restore the anabolic metabolism of cartilage. Compared to glucosamine, enhancing GFPT1 expression with glutamine to influence the hexosamine biosynthetic pathway may offer a more effective therapeutic strategy for OA.
Authors
- Weihua Guo (ORCID: https://orcid.org/0000-0002-9580-513X)
- Xinyu Li (ORCID: https://orcid.org/0000-0001-5136-0303)
- Zhao Zhang (ORCID: https://orcid.org/0000-0002-1389-7262)
- Zeyu Huang
Institutions
- City Of Hope National Medical Center (US)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.intimp.2024.113427
- Citations
- 3
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.86
Funders
- National Natural Science Foundation of China
- Sichuan Province Science and Technology Support Program
- National Key Research and Development Program of China