Changes in circulating extracellular vesicle cargo are associated with cognitive decline after major surgery: an observational case–control study
Our findings highlight the impact of surgery on plasma- and CSF-derived EVs, particularly in patients with poor neurocognitive outcomes, indicating a potential role for EVs. The small sample size necessitates verification with a larger patient cohort.
Authors
- Ákos Végvári (ORCID: https://orcid.org/0000-0002-1287-0906)
- Sven‐Erik Ricksten (ORCID: https://orcid.org/0000-0002-1445-7525)
- Maria Eldh
- Souren Mkrtchian (ORCID: https://orcid.org/0000-0001-9801-2736)
- Susanne Gabrielsson (ORCID: https://orcid.org/0000-0003-1771-1346)
- Mattias Danielson (ORCID: https://orcid.org/0000-0002-9609-5352)
- Marta Gómez‐Galán (ORCID: https://orcid.org/0000-0002-8355-9795)
- Anette Ebberyd
- Jonatan Oras (ORCID: https://orcid.org/0000-0001-8890-6752)
- Lars I. Eriksson
- Andreas Wiklund (ORCID: https://orcid.org/0009-0000-3765-3003)
Institutions
- Karolinska University Hospital (SE)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- British Journal of Anaesthesia
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.bja.2024.07.040
- Citations
- 3
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.27