Evaluation of the effects of a Chinese herb in nonoperative bone fractures in Taiwan: a retrospective multi-central database cohort study

Bone fracture is a critical issue worldwide, affecting daily activities and increasing living expenses. The effect of Chinese herbs on bone union has been evaluated in recent years. However, its clinical efficacy in the unionisation of bone fractures is not completely elucidated. Zheng-Gu-Zi-Jin-Dang (ZGZJD) is a famous formula in Chinese medicine traumatology that has been widely used in patients with fractures in previous studies. We used the Chang Gung Research Database and retrospectively reviewed patients at Chang Gung Memorial Hospital who suffered from bone fractures to evaluate the efficacy of ZGZJD intervention on bone union within 3 months after bone fractures and we used the frequency matching method in a 1:5 ratio for further analysis. Between 2004 and 2016, 291 851 fractures were diagnosed at Chang Gung Memorial Hospital. A total of 544 patients received ZGZJD, and 2 720 patients were match as control which do not use the herbs. However, we adjusted the comorbidities affecting the bone union, sex, age and different body extremities and there were no better healing rate in ZGZJD patient. Although ZGZJD is a common formula used in bone fractures, there is no direct clinical evidence that it enhances bone union. However, according to ingredients analysis in ZGZJD, this famous Chinese traumatology medicine may be useful during the inflammatory phase of bone healing. • The ZGZJD is famous formula used for fracture presented in previous studies. • The CGRD is the largest multi-institutional EMR collection in Taiwan. • The ZGZJD does not directly enhance bone union. • The ZGZJD is suitable for application in the early stage of fracture.