FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver
The results suggest that FITM2 contributes to VLDL lipidation, especially when newly synthesized hepatic TG is in abundance. In addition to its fundamental importance in VLDL assembly, the results also suggest that under dysmetabolic conditions, FITM2 may be an important factor in the partitioning of TG between cytosolic LDs and VLDL particles.
Authors
- Jeffrey L. Brodsky (ORCID: https://orcid.org/0000-0002-6984-8486)
- Meng Carla Wang (ORCID: https://orcid.org/0000-0002-5898-6007)
- Haizhen Wang (ORCID: https://orcid.org/0000-0001-8135-4297)
- Cyrus Nikain
- Özlem Tufanlı (ORCID: https://orcid.org/0000-0003-4388-3571)
- Jaime Amengual
- M. Mahmood Hussain (ORCID: https://orcid.org/0000-0002-9663-300X)
- Yunping Qiu (ORCID: https://orcid.org/0000-0003-1039-5264)
- Min Cai (ORCID: https://orcid.org/0000-0001-6628-0277)
- Ira J. Goldberg (ORCID: https://orcid.org/0000-0002-8701-2201)
- Irwin J. Kurland (ORCID: https://orcid.org/0000-0002-9633-1917)
- Richard Lehner (ORCID: https://orcid.org/0000-0002-6008-1805)
- Russell Watts (ORCID: https://orcid.org/0000-0001-7517-1929)
- Sujith Rajan (ORCID: https://orcid.org/0000-0002-8376-0587)
- Edward A. Fisher (ORCID: https://orcid.org/0000-0001-9802-143X)
- Yong Yu (ORCID: https://orcid.org/0000-0002-0012-3751)
- Konstantinos Fortounas
- Maxwell La Forest (ORCID: https://orcid.org/0000-0003-1794-0413)
Institutions
- Albert Einstein College of Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- University of Alberta (CA)
- University of Illinois Urbana-Champaign (US)
- University of Pittsburgh (US)
- Xiamen University (CN)
- Yunnan Agricultural University (CN)
- Janelia Research Campus (US)
- Cornell University (US)
- New York University (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.molmet.2024.102048
- Citations
- 11
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 3.24
Funders
- American Heart Association
- American Liver Foundation
- National Institutes of Health
- National Cancer Institute