NFATc1 in CD4+ T cells and CD11c+ dendritic cells drives TH2-mediated eosinophilic inflammation in allergic asthma
NFATc1 in T cells and DCs modulates T<sub>H</sub>2-mediated eosinophilic inflammation in allergic asthma, thus offering insight into asthma pathogenesis and identifying NFATc1 as a potential target for therapeutic intervention.
Authors
- Stefan Wirtz (ORCID: https://orcid.org/0000-0001-6936-7431)
- Manfred Rauh (ORCID: https://orcid.org/0000-0002-4852-7157)
- Atefeh Sadeghi Shermeh (ORCID: https://orcid.org/0000-0002-9447-3671)
- Zuqin Yang (ORCID: https://orcid.org/0000-0003-2886-2684)
- Susetta Finotto (ORCID: https://orcid.org/0000-0001-7623-7977)
- Janina C. Grund
- Susanne Krammer (ORCID: https://orcid.org/0000-0002-1445-9555)
- Hannah Mitländer
- Sabine Zirlik
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Comprehensive Cancer Center Erlangen (DE)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.jacig.2024.100355
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- University of Washington
- Deutsche Forschungsgemeinschaft
- Weill Cornell Medical College