Eupalinolide A attenuates trauma-induced heterotopic ossification of tendon in mice by promoting YAP degradation through TOLLIP-mediated selective autophagy
EA could be a potential therapeutic agent for treating traumatic tendon HO. The therapeutic target HECW1 involved in YAP degradation via autophagy presents a new therapeutic avenue to attenuate the progression of traumatic tendon HO.
Authors
- Yan Ding (ORCID: https://orcid.org/0000-0002-9522-1097)
- Yakui Liu (ORCID: https://orcid.org/0000-0001-8274-8255)
- Yongfu Wu (ORCID: https://orcid.org/0000-0002-1245-251X)
- Qinyu Tian (ORCID: https://orcid.org/0000-0001-7572-6736)
- Xinggui Tian (ORCID: https://orcid.org/0000-0003-3619-3943)
- Hebei He (ORCID: https://orcid.org/0009-0005-3336-7671)
- Yingchao Xie (ORCID: https://orcid.org/0009-0003-2163-7430)
- Li Wan (ORCID: https://orcid.org/0000-0001-6426-6498)
- Xuemei Lin (ORCID: https://orcid.org/0000-0001-9267-0842)
- Huaji Jiang (ORCID: https://orcid.org/0000-0003-0197-239X)
- Cheng Yang (ORCID: https://orcid.org/0000-0003-2126-282X)
- Bin Song (ORCID: https://orcid.org/0000-0002-8882-659X)
Institutions
- Huaihua University (CN)
- Sun Yat-sen University (CN)
- Chinese University of Hong Kong (HK)
- Shantou University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Yue Bei People's Hospital (CN)
- Shantou University Medical College (CN)
- University Hospital Carl Gustav Carus (DE)
- First Affiliated Hospital of Jinan University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.phymed.2024.156163
- Citations
- 3
- Primary Topic
- Heterotopic Ossification and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Guangdong Medical Research Foundation
- Southern Medical University
- Guangzhou Science and Technology Program key projects