Phosphodiesterase 5 and its inhibitors with ischaemic heart disease: a Mendelian randomization analysis and a real-world study
This study provided observational and genetic evidence about the protective role of PDE5 inhibition against ischaemic heart disease, indicating the potential of these drugs to be repurposed for ischemia heart disease prevention and treatment.
Authors
- Naiqi Zhang (ORCID: https://orcid.org/0000-0002-0668-7822)
- Jianguang Ji (ORCID: https://orcid.org/0000-0003-0324-9496)
- Yajing Wei
- Ziting Gao
- Jan Sundquist (ORCID: https://orcid.org/0000-0001-7228-5015)
- Wuqing Huang (ORCID: https://orcid.org/0000-0002-7616-8622)
- Kristina Sundquist (ORCID: https://orcid.org/0000-0001-8031-279X)
- Jun Xiao (ORCID: https://orcid.org/0000-0002-5621-840X)
- Ziyi Qiu
- Hongye Wei
Institutions
- Fujian Medical University (CN)
- Malmö University (SE)
- Lund University (SE)
- University of Macau (MO)
- Primary Health Care (QA)
- Union Hospital (US)
- Union Hospital (CN)
Publication Details
- Journal
- European Heart Journal - Cardiovascular Pharmacotherapy
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1093/ehjcvp/pvae081
- Citations
- 3
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Higher Education Discipline Innovation Project
- Fujian Medical University
- Fujian Provincial Health Commission