Low Anti-Tumor Necrosis Factor Levels During Maintenance Phase Are Associated With Treatment Failure in Children With Crohn’s Disease
LD-MTX combination was not associated with higher drug levels, but higher drug levels were associated with reduced risk of treatment failure. Among patients with therapeutic drug levels, we observed no benefit of LD-MTX for patients treated with infliximab. A nonsignificant trend towards reduced treatment failure with the addition of LD-MTX patients treated with adalimumab warrants further investigation.
Authors
- Rana Ammoury (ORCID: https://orcid.org/0009-0003-9645-0451)
- Jeanne Tung (ORCID: https://orcid.org/0000-0001-5949-3717)
- Lourdes Osaba
- Traci Jester
- Jillian S. Sullivan (ORCID: https://orcid.org/0009-0000-7521-1345)
- Michael D. Kappelman (ORCID: https://orcid.org/0000-0002-0469-6856)
- Ann M. Firestine (ORCID: https://orcid.org/0000-0001-9734-9687)
- Charles M. Samson (ORCID: https://orcid.org/0000-0003-3701-7327)
- Jennifer Strople (ORCID: https://orcid.org/0000-0001-5357-9755)
- Steven J. Steiner (ORCID: https://orcid.org/0000-0002-7461-3905)
- Jonathan Moses (ORCID: https://orcid.org/0000-0002-6660-4494)
- Mark Kusek
- Kelly Sandberg (ORCID: https://orcid.org/0000-0001-8927-0434)
- Jill M Dorsey
- Dinesh S. Pashankar (ORCID: https://orcid.org/0000-0003-0815-8809)
- Brendan M. Boyle
- Jess L. Kaplan (ORCID: https://orcid.org/0000-0003-2022-0767)
- Anastasia Ivanova (ORCID: https://orcid.org/0000-0003-4321-2073)
- Prateek Wali (ORCID: https://orcid.org/0000-0001-5638-1226)
- Ian Leibowitz
- Kelly Olano
- Monique Bastidas (ORCID: https://orcid.org/0000-0003-1562-9576)
- Ajay Gulati (ORCID: https://orcid.org/0000-0002-7612-6369)
- Peter A. Margolis (ORCID: https://orcid.org/0000-0002-2585-4630)
- Shehzad A. Saeed (ORCID: https://orcid.org/0000-0002-5534-7891)
- Phillip Minar (ORCID: https://orcid.org/0000-0003-4223-4211)
- Athos Bousvaros
- Jeremy Adler (ORCID: https://orcid.org/0000-0003-1741-7876)
- Dawn R. Ebach (ORCID: https://orcid.org/0000-0001-5399-1387)
- David A. Wohl (ORCID: https://orcid.org/0000-0002-7764-0212)
- Julie Bass
- Pablo J. Palomo
- Barbara Joanna Niklinska-Schirtz
- Tiffany Linville
- Joseph A. Galanko (ORCID: https://orcid.org/0000-0003-2304-4375)
- Hans Herfarth (ORCID: https://orcid.org/0000-0003-4268-823X)
- Keith Benkov (ORCID: https://orcid.org/0000-0003-3232-7705)
- Lisa Pitch (ORCID: https://orcid.org/0000-0002-6937-5754)
- Kelly Chun (ORCID: https://orcid.org/0000-0001-5063-2805)
- José M Cabrera
- M Zikry
- Dorsey M. Bass
- Zarela Molle-Rios
Institutions
- University of North Carolina at Chapel Hill (US)
- Children's Hospital of Wisconsin (US)
- University of Iowa (US)
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- Lurie Children's Hospital (US)
- Nationwide Children's Hospital (US)
- Children's Mercy Hospital (US)
- Children's National (US)
- Harvard University (US)
- Emory University (US)
- George Washington University (US)
- Wright State University (US)
- SUNY Upstate Medical University (US)
- Medical College of Wisconsin (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- LabCorp (United States) (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- University of Vermont Children’s Hospital (US)
- Dayton Children's Hospital (US)
- Grifols (Spain) (ES)
- Levine Children's Hospital (US)
- Stanford Medicine (US)
- Children's Hospital of The King's Daughters (US)
- Children's Healthcare of Atlanta (US)
- C. S. Mott Children's Hospital (US)
- Nemours Children's Clinic (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Nebraska Medical Center (US)
- University of Cincinnati (US)
- University of Oklahoma (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1093/ibd/izae239
- Citations
- 3
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.65
Funders
- Patient-Centered Outcomes Research Institute
- Leona M. and Harry B. Helmsley Charitable Trust