Protein folding dependence on selenoprotein M contributes to steady cartilage extracellular matrix repressing ferroptosis via PERK/ATF4/CHAC1 axis
Our results confirm the involvement of SELM in ER stress-induced cartilage damage as well as protein folding, pointing to new directions in molecular therapy for degenerative diseases.
Authors
- Yongsong Cai
- Shemin Lu
- Dongxian Guo
- Xinyu Huo
- Jingyi Lu
- Peng Hui Xu (ORCID: https://orcid.org/0000-0002-9593-7167)
- Qingxin Song (ORCID: https://orcid.org/0000-0001-7081-3339)
- Jiajun Ren (ORCID: https://orcid.org/0000-0002-1508-4943)
- Chiyuan Ma (ORCID: https://orcid.org/0000-0002-1710-5955)
- Zheng Ying (ORCID: https://orcid.org/0000-0002-1099-0509)
- Yitong Zhao (ORCID: https://orcid.org/0000-0002-0086-2386)
- Yingli He (ORCID: https://orcid.org/0000-0002-6439-012X)
- Li Yao (ORCID: https://orcid.org/0000-0002-2337-799X)
- Lu Wang (ORCID: https://orcid.org/0000-0002-7819-2618)
- Jing Wang (ORCID: https://orcid.org/0000-0002-1891-6426)
- Ru Wang (ORCID: https://orcid.org/0000-0002-2768-1753)
- Rui Wang (ORCID: https://orcid.org/0000-0003-3825-3620)
- Xinyao Wu (ORCID: https://orcid.org/0000-0003-0565-2393)
- Han Li (ORCID: https://orcid.org/0000-0002-0286-3737)
- Rui Luo (ORCID: https://orcid.org/0000-0002-5202-0236)
- Jian Sun
- Haishi Zheng (ORCID: https://orcid.org/0009-0004-5867-8620)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-4835-8541)
Institutions
- National Health and Family Planning Commission (CN)
- Xi'an Honghui Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Microbiology Institute of Shaanxi (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- National Institutes for Food and Drug Control (CN)
- ZheJiang Institute For Food and Drug Control (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Osteoarthritis and Cartilage
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.joca.2024.10.005
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.09