Biofilms and microbiome profiles in chronic wounds: links to antibiotic use and wound severity in a Sri Lankan cohort
CDW microbiomes were dominated by Enterobacteriaceae and Pseudomonadaceae, with elevated Proteobacteria in antibiotic-treated wounds. Alpha diversity correlated with wound severity, peaking in grade 2 wounds. The high prevalence of biofilms in wounds underscores the need for management of CDWs that address microbial complexity.
Authors
- Andrew J. McBain (ORCID: https://orcid.org/0000-0002-5255-5425)
- T Kaluarachchi (ORCID: https://orcid.org/0000-0002-1635-4917)
- Ayomi Dilhari (ORCID: https://orcid.org/0000-0002-8258-9976)
- Manjula Manoji Weerasekera (ORCID: https://orcid.org/0000-0002-8194-2205)
- Paul M. Campbell (ORCID: https://orcid.org/0000-0001-5912-6095)
- Hannah J. Brown (ORCID: https://orcid.org/0000-0003-1188-6858)
- Gavin J. Humphreys (ORCID: https://orcid.org/0000-0002-9138-0859)
- Sujatha Pathirage
- Chinthika Gunasekara
- Neluka Fernando (ORCID: https://orcid.org/0000-0001-7551-8224)
- Anuradha Munasinghe
- Deepaka Weerasekara
Institutions
- University College Dublin (IE)
- University of Sri Jayewardenepura (LK)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Medical Research Institute (LK)
- Universitas Islam Makassar (ID)
Publication Details
- Journal
- Journal of Applied Microbiology
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1093/jambio/lxae262
- Citations
- 1
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.25