Variable-RBE-induced NTCP predictions for various side-effects following proton therapy for brain tumors – Identification of high-risk patients and risk mitigation
The risk of variable-RBE-induced NTCP strongly depends on patient-specific factors and the considered side-effect. A small distance between the tumor and OARs notably increases the risk. Integrating biologically-guided objectives into treatment planning can effectively mitigate the risk.
Authors
- Armin Lühr (ORCID: https://orcid.org/0000-0002-9450-6859)
- Martina Palkowitsch (ORCID: https://orcid.org/0009-0009-7420-208X)
- Mechthild Krause (ORCID: https://orcid.org/0000-0003-1776-9556)
- Annekatrin Seidlitz
- Stefan Menkel
- Fabian Hennings (ORCID: https://orcid.org/0000-0003-3988-4272)
- Steffen Löck (ORCID: https://orcid.org/0000-0002-7017-3738)
- Christian Hahn (ORCID: https://orcid.org/0000-0002-2758-7222)
- Esther G.C. Troost (ORCID: https://orcid.org/0000-0001-9550-9050)
- Jona Bensberg
- Lisa-Marie Kaufmann
Institutions
- TU Dortmund University (DE)
- Heidelberg University (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Heidelberg (DE)
- University Hospital Carl Gustav Carus (DE)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.radonc.2024.110590
- Citations
- 1
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.42