A digital tool for multidimensional assessment and prediction of treatment effectiveness in chronic pain management
Given the multidimensional aspect of pain, the assessment of treatment efficacy is challenging. The prospective observational multicenter PREDIBACK study aimed to assess, compare, and predict the effectiveness of different treatments for persistent spinal pain syndrome type 2 (PSPS-T2) using a digital tool and the Multidimensional Clinical Response Index (MCRI) including pain intensity, functional disability, quality of life, anxiety and depression, and pain surface. Results indicated that neurostimulation was the most effective treatment at 3-, 6-, 9-, and 12-month follow-up compared to baseline, leading to significant improvements in pain, function, and quality of life, whereas optimized medical management (OMM) and spinal reoperation showed no significant benefits. Additionally, the study identified pain surface, BMI, and smoking status as predictors of treatment outcomes. These findings highlight the potential of digital medicine to improve patient care by providing data-driven insights and personalized treatment recommendations for PSPS-T2.
Authors
- Géraldine Brumauld de Montgazon (ORCID: https://orcid.org/0000-0002-8983-3230)
- Philippe Page (ORCID: https://orcid.org/0000-0002-8716-7553)
- Mathilde Many
- Sandrine Baron (ORCID: https://orcid.org/0000-0003-1131-1368)
- Lisa Goudman (ORCID: https://orcid.org/0000-0002-2271-9855)
- Bénédicte Bouche
- Kévin Nivole
- Manuel Roulaud (ORCID: https://orcid.org/0000-0003-3348-7137)
- Bertille Lorgeoux (ORCID: https://orcid.org/0000-0001-9868-2895)
- Nicolas Naïditch
- Philippe Rigoard (ORCID: https://orcid.org/0000-0001-9432-5807)
- Brigitte Roy-Moreau
- Romain David (ORCID: https://orcid.org/0000-0001-5753-4722)
- Amine Ounajim (ORCID: https://orcid.org/0000-0003-2964-6430)
- Maarten Moens (ORCID: https://orcid.org/0000-0003-0577-5449)
- Maxime Billot (ORCID: https://orcid.org/0000-0003-0979-2182)
- Raouf Boukenna
- Lucie Lampert
Institutions
- Centre National de la Recherche Scientifique (FR)
- Vrije Universiteit Brussel (BE)
- Research Foundation - Flanders (BE)
- Institut Pprime (FR)
- Université de Poitiers (FR)
- Centre de Recherches sur la Cognition et l'Apprentissage (FR)
- Nordland Hospital (NO)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Predict (France) (FR)
- Universitair Ziekenhuis Brussel (BE)
- Centre Hospitalier de La Rochelle (FR)
Publication Details
- Journal
- iScience
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.isci.2024.111200
- Citations
- 7
- Primary Topic
- Musculoskeletal pain and rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 3.13
Funders
- Medtronic