DNA methylation at AHRR as a master predictor of smoke exposure and a biomarker for sleep and exercise
Our study suggests that a more rapid return to never-smoker methylation levels after smoking cessation may be achievable in people who change their lifestyle in terms of physical activity and sleep duration. As cigarette smoking has been implicated in the literature as a leading cause of epigenetic aging and AHRR appears to be modifiable by multiple exogenous factors, it emerges as a promising target for intervention and investment.
Authors
- Aneta Sitek (ORCID: https://orcid.org/0000-0002-6802-1997)
- Michał Boroń (ORCID: https://orcid.org/0000-0002-6163-2437)
- Dagmara Lisman (ORCID: https://orcid.org/0000-0003-2876-5665)
- Joanna A Wiktorska
- B. Wysocka (ORCID: https://orcid.org/0009-0009-7297-1336)
- Michał Krzysztofik (ORCID: https://orcid.org/0000-0003-2797-8431)
- Paulina Pruszkowska‐Przybylska (ORCID: https://orcid.org/0000-0002-7826-8715)
- Małgorzata Magdalena Michalczyk (ORCID: https://orcid.org/0000-0003-1590-3002)
- Wojciech Branicki (ORCID: https://orcid.org/0000-0002-7412-5733)
- Magdalena Kobus (ORCID: https://orcid.org/0000-0001-9586-5389)
- Aleksandra Iljin (ORCID: https://orcid.org/0000-0001-8057-4466)
- Rezvan Noroozi (ORCID: https://orcid.org/0000-0003-2294-171X)
- Magdalena Spólnicka (ORCID: https://orcid.org/0000-0001-9230-6274)
- Grażyna Zielińska (ORCID: https://orcid.org/0000-0002-4748-9865)
- Aleksandra Pisarek (ORCID: https://orcid.org/0000-0001-5445-0398)
- Ewelina Pośpiech (ORCID: https://orcid.org/0000-0001-8867-0727)
- Aleksander Masny (ORCID: https://orcid.org/0000-0002-6230-120X)
- Joanna Rudnicka (ORCID: https://orcid.org/0000-0002-4658-3972)
- Kamila Migacz-Gruszka
- Sandra Cytacka (ORCID: https://orcid.org/0000-0002-1961-7639)
- Piotr Kaczka (ORCID: https://orcid.org/0000-0002-1730-6335)
- Andrzej Ossowski (ORCID: https://orcid.org/0000-0002-6819-1638)
Institutions
- Jagiellonian University (PL)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Łódź (PL)
- Medical University of Lodz (PL)
- Centralne Laboratorium Kryminalistyczne Policji (PL)
- Krakow Cardiovascular Research Institute (PL)
- Akademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach (PL)
- University of Warsaw (PL)
- Cardinal Stefan Wyszynski University in Warsaw (PL)
- Pomeranian Medical University (PL)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1186/s13148-024-01757-0
- Citations
- 13
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Narodowe Centrum Badań i Rozwoju