Bidirectional Impact of Varying Severity of Acute Kidney Injury on Calcium Oxalate Stone Formation
Inadequate repair of TECs after severe AKI increases the risk of kidney stone formation, with the upregulation of inflammation-related genes regulated by PKNOX1 playing a role in this process. Inhibiting PKNOX1 function can reduce kidney stone formation. Conversely, after mild AKI, effective cell repair through upregulation of STAT1 expression can protect TEC function and reduce stone formation, and activating STAT1 function can also achieve the goal of treating kidney stones.
Authors
- Haijie Xie
- Junkai Huang (ORCID: https://orcid.org/0000-0003-0026-9934)
- Linguo Xie (ORCID: https://orcid.org/0000-0001-7430-8639)
- Chunyu Liu (ORCID: https://orcid.org/0000-0001-5357-3716)
- Yu Yang (ORCID: https://orcid.org/0000-0002-0122-8643)
- Xiaochen Ma (ORCID: https://orcid.org/0000-0003-4234-412X)
Institutions
- Fudan University (CN)
- Second Hospital of Tianjin Medical University (CN)
- Huashan Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Kidney & Blood Pressure Research
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1159/000542077
- Citations
- 1
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.42