Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease
Our study established MANF as a mechanistic link between ER stress and synapse loss in AD and hinted at MANF as a therapeutic target in AD treatment.
Authors
- Tingting Guo (ORCID: https://orcid.org/0009-0001-8244-7775)
- Xiusheng Chen
- Tingting Xing (ORCID: https://orcid.org/0009-0008-2164-1460)
- Wenzhen Zhu (ORCID: https://orcid.org/0009-0006-9451-5540)
- Xiao‐Xin Yan (ORCID: https://orcid.org/0000-0001-6654-982X)
- Laiqiang Chen (ORCID: https://orcid.org/0000-0001-7374-6864)
- Su Yang (ORCID: https://orcid.org/0000-0002-4925-8710)
- Mingting Shao
- Peng Yin (ORCID: https://orcid.org/0000-0002-4811-6956)
- Yiran Zhang (ORCID: https://orcid.org/0000-0003-3105-5891)
- Qingqing Jia
- Shihua Li (ORCID: https://orcid.org/0000-0001-9044-7137)
- Xiao‐Jiang Li (ORCID: https://orcid.org/0000-0002-9370-8838)
- Huiming Yang (ORCID: https://orcid.org/0000-0002-9722-4232)
- Jiandong Yu (ORCID: https://orcid.org/0000-0003-2731-4512)
Institutions
- Central South University (CN)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1186/s13024-024-00771-3
- Citations
- 5
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China
- Ministry of Science and Technology of the People's Republic of China
- Jinan University
- Guangdong Science and Technology Department