Zhi-Kang-Yin formula attenuates high-fat diet-induced metabolic disorders through modulating gut microbiota-bile acids axis in mice
Our study indicated that the effect of ZKY on improving metabolism is associated with the modulation of GM-BAs axis, especially, by upregulating the abundance of bile salt hydrolase-expression bacteria and increasing the levels of unconjugated BAs. This study indicates that GM-BAs axis might be an important pathway for improving metabolic disorders by ZKY.
Authors
- Yiyang Bao (ORCID: https://orcid.org/0000-0003-2569-2659)
- Weize Zhu (ORCID: https://orcid.org/0000-0002-1830-9474)
- Xinxin Gao (ORCID: https://orcid.org/0009-0004-9337-2061)
- Houkai Li (ORCID: https://orcid.org/0000-0003-2846-7895)
- Yifan Li (ORCID: https://orcid.org/0000-0003-1470-8862)
- Wenjing Wei (ORCID: https://orcid.org/0000-0002-4990-3580)
- Xinyu Ge
- Xiaofang He (ORCID: https://orcid.org/0000-0002-2266-8111)
- Lili Sheng (ORCID: https://orcid.org/0000-0002-1142-6512)
- Wenjin Huang
- Huan Zhang (ORCID: https://orcid.org/0009-0002-8927-2506)
- Tao Zhang (ORCID: https://orcid.org/0000-0002-3151-1642)
- Hao Wang (ORCID: https://orcid.org/0000-0003-2227-075X)
Institutions
- Hunan University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1186/s13020-024-01021-w
- Citations
- 7
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Program of Shanghai Academic Research Leader