Chemotherapy Sparks Tertiary Lymphoid Structures in Metastatic Ovarian Cancer
Ovarian cancer remains resistant to immunotherapy in most patients, highlighting the need to make these tumors more immunogenic. A recent study unveils how chemotherapy is able to induce cancer cell stress in metastatic ovarian carcinomas, inducing the formation of tertiary lymphoid structures that create a "hotter" tumor microenvironment. See related article by Lanickova et al., p. 164.
Authors
- Jesús Bravo Melgar (ORCID: https://orcid.org/0000-0001-6814-6602)
- Damya Laoui (ORCID: https://orcid.org/0000-0002-3373-1403)
Institutions
- Vrije Universiteit Brussel (BE)
- VIB-UGent Center for Inflammation Research (BE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2738
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Fonds Wetenschappelijk Onderzoek
- Vrije Universiteit Brussel
- Vlaams Instituut voor Biotechnologie
- Stichting Tegen Kanker
- Kom op tegen Kanker