Exploring Dietary Factors and Esophageal Adenocarcinoma: Insights From Mendelian Randomization Study

Esophageal adenocarcinoma and diet are not well understood to be associated. We conducted Mendelian randomization analysis using 18 dietary factors as exposures (primarily including fruit consumption, vegetable consumption, alcohol consumption, meat consumption, tea intake, fish intake, etc.), with esophageal adenocarcinoma as the outcome. The IVW method was the leading method used for detecting causal links. Cochran's <i>Q</i> test was utilized to assess heterogeneity, the intercept of the MR-Egger method was used to assess the presence of horizontal pleiotropy, and the existence of outliers was identified via the MR-Presso method. This study identified that both alcohol intake frequency (OR = 1.375, <i>p</i> = 0.0216) and coffee intake (OR = 2.680, <i>p</i> = 0.0304) were linked to a heightened risk of esophageal adenocarcinoma, while raw vegetable/salad consumption (OR = 0.117, <i>p</i> = 0.0258) and dried fruit intake (OR = 0.229, <i>p</i> = 0.00235) were associated with a decreased risk of esophageal adenocarcinoma. After FDR correction, only dried fruit intake (<i>q</i> = 0.0423) remained statistically significant. However, there was no evidence linking the other 14 dietary variables to esophageal adenocarcinoma. This study observed that alcohol consumption and coffee intake increase the risk of esophageal adenocarcinoma, while the intake of dried fruits rather than fresh fruits and raw vegetable intake rather than cooked vegetable intake reduce the risk of esophageal adenocarcinoma. Other dietary factors were not associated with the risk of esophageal adenocarcinoma.