Biomarker pathway heterogeneity of amyloid‐positive individuals
Data-driven modeling identified marker heterogeneity in amyloid-positive individuals. Heterogeneity reflected Alzheimer's disease-like, vascular-like, and mixed pathology presentations. Some amyloid-positive individuals were more similar to amyloid-negative controls. Vascular pathology plays a key role in understanding heterogeneity in those on the amyloid pathway.
Authors
- Josephine Barnes (ORCID: https://orcid.org/0000-0003-3178-025X)
- Lloyd Prosser (ORCID: https://orcid.org/0000-0003-0299-1525)
- Alexandra L. Young (ORCID: https://orcid.org/0000-0002-7772-781X)
- Geert Jan Biessels (ORCID: https://orcid.org/0000-0001-6862-2496)
- Phoebe Walsh (ORCID: https://orcid.org/0000-0001-6584-3111)
- David M. Cash (ORCID: https://orcid.org/0000-0001-7833-616X)
- Carole H. Sudre (ORCID: https://orcid.org/0000-0001-5753-428X)
- Emily N. Manning (ORCID: https://orcid.org/0000-0002-4505-3611)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Hugh Pemberton (ORCID: https://orcid.org/0000-0001-8419-6423)
- Ian B. Malone (ORCID: https://orcid.org/0000-0001-7512-7856)
- Neil P. Oxtoby (ORCID: https://orcid.org/0000-0003-0203-3909)
Institutions
- King's College London (GB)
- University Medical Center Utrecht (NL)
- Amsterdam Neuroscience (NL)
- MRC Unit for Lifelong Health and Ageing (GB)
- NIHR Queen Square Dementia Biomedical Research Unit (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1002/alz.14287
- Citations
- 6
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.96
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Alzheimer's Drug Discovery Foundation
- Eli Lilly and Company
- Biogen
- AbbVie
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Wellcome Trust
- Brain Research Trust
- Wolfson Foundation
- Eisai
- IXICO
- National Institutes of Health
- Genentech
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering