Effect of Vaccination Against E. coli, C. perfringens Type A/C on Piglet Productive and Clinical Parameters Under Field Conditions

<b>Background</b>: One of the main strategies to control neonatal porcine diarrhoea (NPD) is through vaccination of the sows. This study aimed to compare the efficacy of two commercial vaccination schemes under field conditions on a farm where a <i>C. perfringens</i> type A <i>cpb2</i>-positive strain was implicated in NPD. <b>Methods</b>: This study was performed in a farrow-to-wean herd with 5500 sows, already using an <i>E. coli</i> and <i>C. perfringens</i> vaccine but still suffering NPD. Where the presence of a <i>C. perfringens</i> type A <i>cpb2</i>-positive strain was confirmed, Enteroporc Coli AC^® (Ceva) was administrated to the sows in group A according to the manufacturer's instructions. Sows in group B were vaccinated using two other combined commercial vaccines. In each group, piglets from 10 litters were ear-tagged and individually weighed at birth and at 8 and 22 days of age. The incidence of diarrhoea, general piglet body condition, and antimicrobial treatment were recorded within 10 consecutive days after birth. <b>Results</b>: A total of 234 piglets (119 in group A and 115 in group B) were included. The mean weight gain of piglets from birth to 22 days of age was significantly higher in group A (4.99 kg) than in group B (4.66 kg) (<i>p</i> = 0.039). The rest of the recorded parameters such as the presence of diarrhoea, the piglet’s body condition score, the number of days with antimicrobial treatment, and preweaning mortality, did not differ significantly between groups. <b>Conclusions</b>: This study confirmed the efficiency of the Enteroporc Coli AC^® vaccine in reducing clinical symptoms of diarrhoea in piglets, which was comparable with the other vaccines used in the study. The positive effect on piglets' productive performance during the lactation phase was observed.