Evaluation of a multiplexed immunoassay for assessing long-term humoral immunity Orthopoxviruses
Overall, this assay demonstrates high sensitivities in detecting antibodies for multiple relevant MPXV and VACV antigens post-infection and post-vaccination, indicating its utility in understanding immune responses to Orthopoxviruses in current and future outbreaks and evaluating the immunogenicity of new-generation Mpox-specific vaccinations.
Authors
- Bethany Hicks (ORCID: https://orcid.org/0000-0003-0055-9771)
- Ezra Linley (ORCID: https://orcid.org/0000-0002-5935-6154)
- Scott Jones (ORCID: https://orcid.org/0000-0001-6006-2455)
- Tommy Rampling (ORCID: https://orcid.org/0000-0001-9111-2486)
- D. R. C. Bailey (ORCID: https://orcid.org/0000-0002-8184-1754)
- Marcus Pond (ORCID: https://orcid.org/0000-0002-6267-7960)
- Clarissa Oeser (ORCID: https://orcid.org/0000-0003-1939-1964)
- Helen Callaby
- Ravi Mehta (ORCID: https://orcid.org/0000-0001-8211-1721)
- Rachael Jones
- Ashley Otter (ORCID: https://orcid.org/0000-0002-8317-9194)
- Simon Tonge (ORCID: https://orcid.org/0000-0002-3832-2334)
- Bassam Hallis
- Catherine Houlihan (ORCID: https://orcid.org/0000-0002-7539-1566)
- Cathy Rowe
- Deborah Wright
- Claire Gordon
Institutions
- National Health Service (GB)
- Imperial College Healthcare NHS Trust (GB)
- University of Aberdeen (GB)
- Chelsea and Westminster Hospital NHS Foundation Trust (GB)
- Wiltshire College (GB)
- Public Health England (GB)
- UK Health Security Agency (GB)
Publication Details
- Journal
- Vaccine
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1016/j.vaccine.2024.126453
- Citations
- 6
- Primary Topic
- Poxvirus research and outbreaks
- Type
- article
- Field-Weighted Citation Impact
- 1.76