Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance
These data demonstrate that inhibition of phosphatases carried by EVs from IR participants rescues insulin signalling in adipocytes and hepatocytes and point towards PTP1B and PP2A carried by IR EVs as being novel potential therapeutic targets against insulin resistance in adipose tissue and liver and the development of obesity.
Authors
- Gilles Simard (ORCID: https://orcid.org/0000-0002-0223-1422)
- Maria Carmen Martínez (ORCID: https://orcid.org/0000-0003-3897-7397)
- Sarah Kamli-Salino (ORCID: https://orcid.org/0000-0002-5107-5366)
- Mirela Delibegović (ORCID: https://orcid.org/0000-0001-6193-3152)
- Séverine Dubois (ORCID: https://orcid.org/0000-0002-8167-7915)
- Luisa Vergori (ORCID: https://orcid.org/0000-0002-4546-3661)
- Megan Piquet
- Pascal Pomiès (ORCID: https://orcid.org/0000-0002-5301-6087)
- Pierre‐Henri Ducluzeau (ORCID: https://orcid.org/0000-0002-2515-241X)
- Samir Henni (ORCID: https://orcid.org/0000-0002-9838-481X)
- Xavier Vidal‐Gómez (ORCID: https://orcid.org/0000-0002-7640-7996)
- Ramaroson Andriantsitohaina (ORCID: https://orcid.org/0000-0002-4770-3585)
- Sakina Ali
- Frédéric Gagnadoux (ORCID: https://orcid.org/0000-0002-4231-5102)
Institutions
- Université de Tours (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Aberdeen (GB)
- Université de Montpellier (FR)
- Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Laboratoire Stress Oxydant et Pathologies Métaboliques (FR)
- Université d'Angers (FR)
Publication Details
- Journal
- Diabetologia
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1007/s00125-024-06288-0
- Citations
- 10
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Fondation de France
- Universite Angers