The population-specific Thr44Met OCT3 coding variant affects metformin pharmacokinetics with subsequent effects on insulin sensitivity in C57Bl/6J mice
These data provide evidence that the SLC22A3 rs8187715 variant accelerates metformin uptake rate in vivo. While this acutely improves insulin sensitivity, there was no increased effect of metformin with longer-term dosing. Thus, our finding of a high prevalence of this variant specifically in Māori and Pacific peoples identifies it as a potential population-specific pharmacogenetic marker with potential to guide metformin therapy in these peoples.
Authors
- Peter R. Shepherd (ORCID: https://orcid.org/0000-0001-9742-5811)
- Prasanna Kallingappa (ORCID: https://orcid.org/0000-0002-2834-6148)
- Qian Wang (ORCID: https://orcid.org/0000-0001-7432-8613)
- Rinki Murphy (ORCID: https://orcid.org/0000-0002-0043-2423)
- Troy L. Merry (ORCID: https://orcid.org/0000-0001-8699-500X)
- Waruni C. Dissanayake (ORCID: https://orcid.org/0000-0002-0477-9619)
- Pearce Wilcox (ORCID: https://orcid.org/0000-0001-8485-6962)
- Megan Leask (ORCID: https://orcid.org/0000-0003-3199-5277)
- Huti Watson (ORCID: https://orcid.org/0009-0007-5055-6081)
- Jagdish K. Jaiswal
- Christine A. O’Sullivan (ORCID: https://orcid.org/0009-0001-5254-6078)
- Chris Puli’uvea (ORCID: https://orcid.org/0009-0006-4467-7744)
- Kate Lee
Institutions
- University of Auckland (NZ)
- Good Shepherd College (NZ)
- University of Alabama at Birmingham (US)
- Auckland University of Technology (NZ)
- Cancer Society of New Zealand (NZ)
- Maurice Wilkins Centre (NZ)
- University of Otago (NZ)
Publication Details
- Journal
- Diabetologia
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1007/s00125-024-06287-1
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- University of Otago
- University of Auckland
- Maurice Wilkins Centre for Molecular Biodiscovery
- Health Research Council of New Zealand