Plasma exchange and intravenous immunoglobulin prolonged the survival of a porcine kidney xenograft in a sensitized, brain-dead human recipient
5GE and clinical-grade immunosuppressive regimens were sufficient to prevent hyperacute rejection during pig-to-human kidney xenotransplantation. Pre-existing anti-porcine antibodies predisposed the xenograft to AMR. Plasma exchange and intravenous immunoglobulin were safe and effective in the treatment of AMR after kidney xenotransplantation.
Authors
- Donghui Han (ORCID: https://orcid.org/0000-0002-3742-4355)
- Zhang Yang (ORCID: https://orcid.org/0000-0002-4756-5813)
- Xiaozheng Fan
- Ruochen Qi (ORCID: https://orcid.org/0000-0001-9073-4996)
- Kaishan Tao (ORCID: https://orcid.org/0000-0002-8573-0445)
- Kepu Liu
- Zhao-Xu Yang (ORCID: https://orcid.org/0000-0002-8864-5377)
- Shuaijun Ma
- Di Wei (ORCID: https://orcid.org/0000-0003-2670-6362)
- Jing Li (ORCID: https://orcid.org/0000-0003-4552-7888)
- Xuan Zhang (ORCID: https://orcid.org/0000-0003-2937-9141)
- Xiaoyan Zhang (ORCID: https://orcid.org/0000-0002-4060-2423)
- Guohui Wang (ORCID: https://orcid.org/0000-0002-3777-8540)
- Xiaojian Yang (ORCID: https://orcid.org/0000-0003-1337-0513)
- Zhe Wang (ORCID: https://orcid.org/0000-0002-7573-1583)
- Jingliang Zhang
- Zhengxuan Li (ORCID: https://orcid.org/0000-0001-9907-1543)
- Shichao Han (ORCID: https://orcid.org/0000-0001-5404-7347)
- Yanyan Jia (ORCID: https://orcid.org/0000-0003-0740-8028)
- Kefeng Dou
- Weijun Qin (ORCID: https://orcid.org/0009-0000-4794-3565)
- Dengke Pan
- Tong Xu
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1097/cm9.0000000000003338
- Citations
- 6
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 3.44