Evidence of Site‐Specific Mucosal Autoantibody Secretion in Rheumatoid Arthritis
Our study shows the presence of ACPA, anti-CarP, and AAPA IgA in saliva of ACPA-seropositive patients with RA. However, no AMPA could be detected in feces/ileal wash samples of these patients, although our assays were able to measure other antigen-specific antibodies. These data suggest that mucosal autoantibody secretion may occur in the oral mucosa of patients with RA, whereas no evidence could be found for this process in the lower gastrointestinal tract.
Authors
- Wendy Walrabenstein (ORCID: https://orcid.org/0000-0002-2428-2845)
- Diane van der Woude (ORCID: https://orcid.org/0000-0001-8121-5879)
- Alf Kastbom (ORCID: https://orcid.org/0000-0001-7187-1477)
- K. Martinsson (ORCID: https://orcid.org/0000-0003-4492-9172)
- Anna Svärd (ORCID: https://orcid.org/0000-0002-2470-4307)
- René E. M. Toes (ORCID: https://orcid.org/0000-0002-9618-6414)
- T. Huizinga (ORCID: https://orcid.org/0000-0001-7033-7520)
- Carlijn A. Wagenaar (ORCID: https://orcid.org/0000-0002-0937-4450)
- V. Derksen (ORCID: https://orcid.org/0000-0002-8246-7055)
- Daniel Sjöberg (ORCID: https://orcid.org/0000-0002-9082-8017)
- Anouk G. van Mourik (ORCID: https://orcid.org/0000-0002-3811-7373)
- Dirkjan van Schaardenburg
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Leiden University Medical Center (NL)
- Falun Hospital (SE)
- Reade (NL)
- Center for Clinical Research Dalarna (SE)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1002/art.43036
- Citations
- 7
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 2.83