Association of Gut Microbiota With Fatigue in Black Women With Polycystic Ovary Syndrome
Black women with PCOS experience mild to moderate fatigue. Clinicians should be cognizant of this population's increased risk for fatigue to adequately address their healthcare needs. We also found that gut microbial composition was associated with fatigue in Black women with PCOS. Specifically, a higher relative abundance of certain gut bacteria involved in short-chain fatty acid production and anti-inflammatory pathways was correlated with lower fatigue levels. Future studies should further investigate the link between the gut microbiome and fatigue to determine whether this relationship is causal as better insight could inform tailored diet and exercise interventions to alter the gut microbiome and reduce fatigue.
Authors
- Natalia Kosyakova (ORCID: https://orcid.org/0000-0002-8213-8438)
- Jordan Pelkmans (ORCID: https://orcid.org/0000-0001-9917-5369)
- Laren Riesche (ORCID: https://orcid.org/0000-0002-3327-4089)
- J. Slack (ORCID: https://orcid.org/0000-0001-8358-845X)
- Sandra B. Dunbar (ORCID: https://orcid.org/0000-0001-8752-2343)
- Jessica B. Spencer (ORCID: https://orcid.org/0000-0001-8156-514X)
- Erin P. Ferranti (ORCID: https://orcid.org/0000-0002-2332-9349)
- Madelyn C. Houser (ORCID: https://orcid.org/0000-0002-4049-9876)
Institutions
- National Institutes of Health (US)
- U.S. National Science Foundation (US)
- University of Connecticut (US)
- Emory University (US)
- Duke University (US)
- National Institute of Nursing Research (US)
Publication Details
- Journal
- Nursing Research
- Published
- 2024-10-07
- DOI
- https://doi.org/10.1097/nnr.0000000000000788
- Citations
- 4
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.15