Prostate cancer cell-derived exosomes ZNF667-AS1 reduces TGFBR1 mRNA stability to inhibit Treg expansion and DTX resistance by binding to U2AF1
ZNF667-AS1 suppressed cell growth of PC cells, tumor growth of mice and DTX resistance to PC cells and exogenously high ZNF667-AS1 expression in tumor-derived exosomes destabilized TGFBR1 mRNA and reduce TGFBR1 expression through interacting with U2AF1, thus resulting in attenuated Treg expansion, which was related to DTX resistance.
Authors
- Jiuzhi Li
- Bide Liu (ORCID: https://orcid.org/0000-0002-7296-5907)
- Wenjing Pu
- Zhiwei Li (ORCID: https://orcid.org/0009-0006-4972-4570)
- Min Li (ORCID: https://orcid.org/0000-0002-0188-1394)
- Min Sun (ORCID: https://orcid.org/0000-0002-7049-5526)
- Xiaoan Zhang (ORCID: https://orcid.org/0000-0002-7003-4543)
- Shuo Li (ORCID: https://orcid.org/0009-0006-9343-8619)
- Zhenfeng Shi (ORCID: https://orcid.org/0009-0001-0260-3097)
- Mierzhayiti Aihemaitijiang (ORCID: https://orcid.org/0009-0003-4724-095X)
Institutions
- Xinjiang Medical University (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1186/s10020-024-00947-z
- Citations
- 7
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Natural Science Foundation of Xinjiang Province
- National Natural Science Foundation of China