Identification of novel drug targets for Helicobacter pylori: structure-based virtual screening of potential inhibitors against DAH7PS protein involved in the shikimate pathway
This study identified 54 novel drug targets against <i>H. pylori</i>. The DAH7PS protein as a promising drug target was evaluated using a computer-aided drug design. 6,8-Dihydroxyisocoumarin-3-carboxylic acid and Epicatechin demonstrated desirable properties and stable interactions, highlighting their potential to inhibit DAH7PS as an essential protein. Undoubtedly, more experimental validations are needed to advance these findings into practical therapies for treating drug-resistant <i>H. pylori</i>.
Authors
- Farzad Badmasti (ORCID: https://orcid.org/0000-0003-3502-147X)
- Narjes Noori Goodarzi (ORCID: https://orcid.org/0000-0001-9786-6182)
- Nader Rahimi (ORCID: https://orcid.org/0000-0002-6745-1725)
- Behzad Shahbazi (ORCID: https://orcid.org/0000-0002-0903-2960)
- Mahshid Khazani Asforooshani
Institutions
- Pasteur Institute of Iran (IR)
- Shiraz University of Medical Sciences (IR)
- Semnan University of Medical Sciences (IR)
- Alzahra University (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Bioinformatics
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3389/fbinf.2024.1482338
- Citations
- 7
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01