Comparative analysis of the effects of cyclophosphamide and dexamethasone on intestinal immunity and microbiota in delayed hypersensitivity mice
The study demonstrates that CY and DEX have distinct regulatory effects on the immune organ index, distribution of T cell subsets, and diversity and structure of gut microbiota on DTH-induced immune responses mice, suggesting their differential influence on intestinal mucosal immunity. These findings have implications for the development of targeted immunotherapies and understanding the interplay between immunosuppressive drugs and gut microbiota.
Authors
- Li Lü (ORCID: https://orcid.org/0000-0002-3905-1273)
- Xia Luo (ORCID: https://orcid.org/0000-0002-0641-9182)
- Ruyan Wen (ORCID: https://orcid.org/0000-0002-0797-556X)
- Xiangling Li (ORCID: https://orcid.org/0000-0003-3393-3352)
- Junlong Yu
- Jun Ai (ORCID: https://orcid.org/0000-0002-2992-5854)
- Ben Chen
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangxi University (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1371/journal.pone.0312147
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Guangxi University