Efficacy, safety and tolerability of GSK3858279, an anti-CCL17 monoclonal antibody and analgesic, in healthy volunteers and patients with knee osteoarthritis pain: a phase I, randomised, double-blind, placebo-controlled, proof-of-mechanism and proof-
GSK3858279 improved pain intensity and WOMAC pain and function scores in adults with knee OA pain and demonstrated favourable safety and tolerability in both healthy participants and adults with knee OA pain.
Authors
- Eirini Panoilia
- Rejbinder Kaur
- Catherine Muya
- Kiran Nistala
- Katharine Abbott-Banner
- Christian D. Ellson
- David R. Inman (ORCID: https://orcid.org/0000-0001-5820-4688)
- Julia E. Smith (ORCID: https://orcid.org/0000-0002-9634-9471)
- Edward C. Emery (ORCID: https://orcid.org/0000-0001-9723-8661)
- Louise K. Modis (ORCID: https://orcid.org/0000-0003-3103-4089)
- N S Aston
- Maria Feeney (ORCID: https://orcid.org/0000-0001-6590-2927)
- Damon Bass (ORCID: https://orcid.org/0000-0003-2480-5674)
- Disala Fernando
- Riju Ray (ORCID: https://orcid.org/0000-0002-2540-4533)
- Jagtar Singh Nijjar (ORCID: https://orcid.org/0000-0003-4947-6299)
- Joanne Ellis (ORCID: https://orcid.org/0000-0001-7873-4571)
- Sarah Siederer (ORCID: https://orcid.org/0000-0001-6408-7393)
- Lucinda Weir (ORCID: https://orcid.org/0000-0002-3563-6100)
- Nicolas Wisniacki (ORCID: https://orcid.org/0000-0002-1681-9948)
- Yolanda Alvarez (ORCID: https://orcid.org/0000-0001-6367-0165)
- Jane H. Bentley
- Sam Munoz Vicente
Institutions
- Research Triangle Park Foundation (US)
- Providence College (US)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1136/ard-2023-225434
- Citations
- 10
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 4.48