The human claustrum tracks slow waves during sleep
Slow waves are a distinguishing feature of non-rapid-eye-movement (NREM) sleep, an evolutionarily conserved process critical for brain function. Non-human studies suggest that the claustrum, a small subcortical nucleus, coordinates slow waves. We show that, in contrast to neurons from other brain regions, claustrum neurons in the human brain increase their spiking activity and track slow waves during NREM sleep, suggesting that the claustrum plays a role in coordinating human sleep architecture.
Authors
- Christopher Pittenger (ORCID: https://orcid.org/0000-0003-2117-9321)
- Alfred P. Kaye (ORCID: https://orcid.org/0000-0002-3153-1221)
- Mingli Liang (ORCID: https://orcid.org/0000-0002-0668-8489)
- Eyiyemisi C. Damisah (ORCID: https://orcid.org/0000-0001-8854-1335)
- Kevin Navin Sheth (ORCID: https://orcid.org/0000-0003-2003-5473)
- Layton Lamsam (ORCID: https://orcid.org/0000-0002-5792-7320)
- John Harrison Krystal (ORCID: https://orcid.org/0000-0001-6952-1726)
- Lawrence J. Hirsch (ORCID: https://orcid.org/0000-0002-6333-832X)
- Brett Gu
- George Sun (ORCID: https://orcid.org/0000-0002-3879-6556)
- Kamren J. Khan
Institutions
- Yale University (US)
- National Center for PTSD (US)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1038/s41467-024-53477-x
- Citations
- 8
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 2.74
Funders
- Yale University
- National Institutes of Health