Single-cell transcriptomics reveal potent extrafollicular B cell response linked with granzyme K+ CD8 T cell activation in lupus kidney
Our study revealed a potent extrafollicular B cell response linked with overactivation of GZMK<sup>+</sup> CD8 T cells in the kidney of patients with LN, which may lead to innovative treatments for LN.
Authors
- Mingyuan Wang (ORCID: https://orcid.org/0000-0001-8965-8391)
- Chunde Bao
- Min Dai (ORCID: https://orcid.org/0000-0002-1681-6990)
- Shuang Ye (ORCID: https://orcid.org/0000-0002-5257-5768)
- Fang Du (ORCID: https://orcid.org/0000-0002-9614-9517)
- Zechuan Chen (ORCID: https://orcid.org/0000-0003-4363-5949)
- Qiong Fu (ORCID: https://orcid.org/0000-0001-5873-6422)
- Xixi Gu (ORCID: https://orcid.org/0009-0009-4527-0315)
- Xiaodong Wang (ORCID: https://orcid.org/0000-0002-2945-9240)
- Ting Li (ORCID: https://orcid.org/0000-0001-6800-6650)
- Yan Ye (ORCID: https://orcid.org/0009-0009-3203-9173)
- Xiaoming Zhang (ORCID: https://orcid.org/0000-0001-6732-9132)
- Shan Jiang (ORCID: https://orcid.org/0000-0002-7895-2058)
- Chunmei Wu
- Longhai Tang
- Teng Li (ORCID: https://orcid.org/0000-0003-2577-3985)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Cell Therapy Research Institute (CN)
- Institute of Infection and Immunity (CA)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1136/ard-2024-225876
- Citations
- 21
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 9.87
Funders
- National Natural Science Foundation of China