Exploring the mechanism of action of Modified Simiao Powder in the treatment of osteoarthritis: an in-silico study
The therapeutic effect of MSMP likely attributed to the modulation of multiple pathways, including lipid metabolism, atherosclerosis, the AGE-RAGE signaling pathway, and the PI3K-Akt signaling pathway, by the active components such as berberine, kaempferol, luteolin, and quercetin. Especially, their actions on target genes like AR and AKT1 contribute to the therapeutic benefits of MSMP observed in the treatment of OA.
Authors
- Qinglai Wang (ORCID: https://orcid.org/0009-0007-0907-4793)
- Pingping Su (ORCID: https://orcid.org/0009-0004-4259-510X)
- Yibo Zhu
- Xiahui Zhou
- Zhouhengte Xu
- Zhihui Zheng
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3389/fmed.2024.1422306
- Citations
- 4
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.87