Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells
Overall, these results have identified an association between two cytokines of the IL-17 family (IL-17D and IL-17F) with COVID-19 and disease severity. Considering that IL-17F stimulation promotes neutrophil adhesion to the endothelium in a MAPK-dependent manner, it is attractive to speculate that this pathway may contribute to pathogenic immunothrombosis in concert with other molecular effectors.
Authors
- Amin Emad (ORCID: https://orcid.org/0000-0002-5108-4887)
- Katelyn Yixiu Liu
- Lyvia Fourcade
- Douglas D. Fraser (ORCID: https://orcid.org/0000-0002-5635-3791)
- Antoine Soulé (ORCID: https://orcid.org/0000-0003-4810-4821)
- Simon Rousseau (ORCID: https://orcid.org/0000-0002-8773-575X)
- Jérôme Bédard-Matteau
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- McGill University Health Centre (CA)
- Children’s Health Research Institute (CA)
- Mila - Quebec Artificial Intelligence Institute (CA)
- McGill University (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.3389/fimmu.2024.1452788
- Citations
- 10
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- Public Health Agency of Canada
- Canadian Lung Association
- Public Health Agency
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé